Exposure to low dose ionising radiation: molecular and clinical consequences

LM Martin, B Marples, TH Lynch, D Hollywood… - Cancer letters, 2013 - Elsevier
This review article provides a comprehensive overview of the experimental data detailing
the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS) …

Clinical studies on ultrafractionated chemoradiation: A systematic review

E Scirocco, F Cellini, A Zamagni, G Macchia… - Frontiers in …, 2021 - frontiersin.org
Aim The efficacy of low-dose fractionated radiotherapy (LDFRT) and chemotherapy (CHT)
combination has large preclinical but little clinical evidence. Therefore, the aim of this review …

Impact of time interval and dose rate on cell survival following low-dose fractionated exposures

S Terashima, Y Hosokawa, E Tsuruga… - Journal of radiation …, 2017 - academic.oup.com
Enhanced cell lethality, also known as hyper-radiosensitivity, has been reported at low
doses of radiation (≤ 0.5 Gy) in various cell lines, and is expected to be an effective cancer …

Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study

M Balducci, S Chiesa, B Diletto, GR D'Agostino… - Neuro …, 2012 - academic.oup.com
We explored the feasibility of concurrent palliative chemotherapy and low-dose fractionated
radiotherapy (LD-FRT) in glioblastoma multiforme (GBM). Patients with …

The role and mechanism of ATM-mediated autophagy in the transition from hyper-radiosensitivity to induced radioresistance in lung cancer under low-dose radiation

Q Wang, Y Chen, H Chang, T Hu, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Objective: This study aimed to investigate the effect of ataxia telangiectasia mutated (ATM)–
mediated autophagy on the radiosensitivity of lung cancer cells under low-dose radiation …

Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: a cell line study in four glioblastoma multiforme (GBM) cell …

D Schoenherr, SA Krueger, L Martin… - … journal of radiation …, 2013 - Taylor & Francis
Purpose: To determine if ultra-fractionation using repeated pulses of radiation (10× 0.2 Gray
[Gy]) would be more cytotoxic than continuously-delivered radiation to the same total dose (2 …

The predictive value of 18F-FDG PET-CT for assessing the clinical outcomes in locally advanced NSCLC patients after a new induction treatment: low-dose …

MV Mattoli, M Massaccesi, A Castelluccia, V Scolozzi… - Radiation …, 2017 - Springer
Background Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have
poor prognosis despite several multimodal approaches. Recently, low-dose fractionated …

Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study

G Mantini, V Valentini, B Meduri, S Margaritora… - Radiotherapy and …, 2012 - Elsevier
PURPOSE: Low-dose radiotherapy (LDR)(< 50cGy) induces enhanced cell killing in vitro via
the hyper-radiation sensitivity phenomenon. Aim of this study was to evaluate the safety and …

A feasibility study of neo-adjuvant low-dose fractionated radiotherapy with two different concurrent anthracycline-docetaxel schedules in stage IIA/B-IIIA breast cancer

L Nardone, V Valentini, L Marino… - Tumori …, 2012 - journals.sagepub.com
Aims and Background The aim of the study was to evaluate the feasibility of neoadjuvant low-
dose fractionated radiotherapy, in combination with two anthracycline-docetaxel regimens …

Low-dose fractionated radiotherapy and concomitant chemotherapy for recurrent or progressive glioblastoma

M Balducci, B Diletto, S Chiesa… - Strahlentherapie …, 2014 - search.proquest.com
Low-dose fractionated radiotherapy and concomitant chemotherapy for recurrent or progressive
glioblastoma Page 1 Strahlenther Onkol 2014 · 190:370–376 DOI 10.1007/s00066-013-0506-z …