Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Preventive and therapeutic strategies in Alzheimer's disease: focus on oxidative stress, redox metals, and ferroptosis

G Plascencia-Villa, G Perry - Antioxidants & redox signaling, 2021 - liebertpub.com
Significance: Alzheimer's disease (AD) is the most common cause of dementia in the elderly.
AD is currently ranked as the sixth leading cause of death, but some sources put it as third …

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

OV Forlenza, M Radanovic, LL Talib… - The British Journal of …, 2019 - cambridge.org
BackgroundExperimental studies indicate that lithium may facilitate neurotrophic/protective
responses in the brain. Epidemiological and imaging studies in bipolar disorder, in addition …

[HTML][HTML] Small molecule therapeutics for tauopathy in Alzheimer's disease: walking on the path of most resistance

L Wang, R Kumar, PF Pavlov, B Winblad - European journal of medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …

Long-term lithium therapy: side effects and interactions

E Ferensztajn-Rochowiak, JK Rybakowski - Pharmaceuticals, 2023 - mdpi.com
Lithium remains the drug of first choice for prophylactic treatment of bipolar disorder,
preventing the recurrences of manic and depressive episodes. The longitudinal experiences …

[HTML][HTML] Early diagnosis and treatment of Alzheimer's disease: new definitions and challenges

M Pais, L Martinez, O Ribeiro, J Loureiro… - Brazilian Journal of …, 2020 - SciELO Brasil
The prevalence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
expected to more than double by 2050. Studies on the pathophysiology of AD have been …

Precision Nutrition for Alzheimer's Prevention in ApoE4 Carriers

NG Norwitz, N Saif, IE Ariza, RS Isaacson - Nutrients, 2021 - mdpi.com
The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer's disease, a
condition that is increasing in prevalence and remains without a cure. Precision nutrition …

Molecular mechanisms and therapeutic potential of lithium in Alzheimer's disease: repurposing an old class of drugs

Y Shen, M Zhao, P Zhao, L Meng, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline and memory loss. Despite advances in understanding the …

Association between estimated geocoded residential maternal exposure to lithium in drinking water and risk for autism spectrum disorder in offspring in Denmark

Z Liew, Q Meng, Q Yan, J Schullehner… - JAMA …, 2023 - jamanetwork.com
Importance Lithium is a naturally occurring and trace element that has mood-stabilizing
effects. Maternal therapeutic use of lithium has been associated with adverse birth …

[HTML][HTML] Antiviral, immunomodulatory, and neuroprotective effect of lithium

JK Rybakowski - Journal of integrative neuroscience, 2022 - imrpress.com
Currently, in psychiatry, lithium is a drug of choice as a mood stabilizer in the maintenance
treatment of bipolar disorder for the prevention of manic and depressive recurrences. The …