New insights into pre-BCR and BCR signalling with relevance to B cell malignancies
RC Rickert - Nature Reviews Immunology, 2013 - nature.com
The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …
[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
A Wiestner - Blood, The Journal of the American Society of …, 2012 - ashpublications.org
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells that depend on host
factors in the tissue microenvironment for survival and proliferation. In vitro, CLL cells rapidly …
factors in the tissue microenvironment for survival and proliferation. In vitro, CLL cells rapidly …
BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199
Abstract The Bcl-2 antagonist ABT-199 (venetoclax) has demonstrated promising clinical
activity in patients with chronic lymphocytic leukemia (CLL). ABT-199 is strongly cytotoxic …
activity in patients with chronic lymphocytic leukemia (CLL). ABT-199 is strongly cytotoxic …
[HTML][HTML] The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy
G Packham, S Krysov, A Allen, N Savelyeva… - …, 2014 - ncbi.nlm.nih.gov
Biologists and clinicians agree that the B-cell receptor influences the behavior of chronic
lymphocytic leukemia, and promising new drugs are aimed at receptor-associated kinases …
lymphocytic leukemia, and promising new drugs are aimed at receptor-associated kinases …
The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia
B cell receptor (BCR) signaling is a central pathway promoting the survival and proliferation
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells
JC Godbersen, LA Humphries, OV Danilova… - Clinical cancer …, 2014 - AACR
Background: Stromal-mediated signaling enhances NF-κB pathway activity in chronic
lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance …
lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance …
Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia
MS Davids, J Deng, A Wiestner… - Blood, The Journal …, 2012 - ashpublications.org
Stroma induces treatment resistance in chronic lymphocytic leukemia (CLL), possibly
because of alterations in the BCL-2 family of proteins, which are key regulators of apoptosis …
because of alterations in the BCL-2 family of proteins, which are key regulators of apoptosis …
Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT …
Duvelisib, an oral dual inhibitor of PI3K-δ and PI3K-γ, is in phase III trials for the treatment of
chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin's lymphoma. In CLL …
chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin's lymphoma. In CLL …
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer
Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …