Abstract Taiwan's National Health Insurance Research Database (NHIRD) exemplifies a
population-level data source for generating real-world evidence to support clinical decisions …

Objective Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy,
particularly in Helicobacter pylori (HP)-infected subjects. We determined the association …

Background To reduce prescribing cascades occurring in clinical practice, healthcare
providers require information on the prescribing cascades they can recognize and prevent …

Background Although prior studies showed metformin could reduce gastric cancer (GC) risk
in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and …

Sequence symmetry analysis (SSA) is a method for detecting adverse drug events by
utilizing computerized claims data. The method has been increasingly used to investigate …

Background The (prescription) sequence symmetry analysis (PSSA) design has been used
to identify potential prescribing cascade signals by assessing the prescribing sequence of …

Introduction: With increasing availability, the use of healthcare databases as complementary
data source for drug safety signal detection has been explored to circumvent the limitations …

Importance Calcium channel blockers, specifically dihydropyridine calcium channel blockers
(DH CCBs, eg, amlodipine), may cause lower-extremity edema. Anecdotal reports suggest …

The misattribution of an adverse drug reaction (ADR) as a symptom or illness can lead to the
prescribing of additional medication, referred to as a prescribing cascade. The aim of this …

Introduction: Warfarin and direct oral anticoagulants (DOACs) have been widely used in
antithrombotic therapy. Although warfarin use has been suspected to be associated with …