Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota

L Micheli, L Bertini, A Bonato, N Villanova, C Caruso… - Nutrients, 2023 - mdpi.com
Aging is a multi-faceted process caused by the accumulation of cellular damage over time,
associated with a gradual reduction of physiological activities in cells and organs. This …

Combating Parkinson's disease with plant-derived polyphenols: Targeting oxidative stress and neuroinflammation

RM Gahtani, S Shoaib, U Hani, R Jayachithra… - Neurochemistry …, 2024 - Elsevier
Parkinson's disease (PD) is a devastating neurodegenerative disorder predominantly
affecting the elderly, characterized by the loss of dopaminergic neurons in the substantia …

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats

HA Farid, RH Sayed, MES El-Shamarka… - …, 2024 - Springer
Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …

Unraveling the AKT/ERK cascade and its role in Parkinson disease

PK Keshri, SP Singh - Archives of Toxicology, 2024 - Springer
Parkinson disease represents a significant and growing burden on global healthcare
systems, necessitating a deeper understanding of their underlying molecular mechanisms …

The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products

L Gao, XN Yang, YX Dong, YJ Han, XY Zhang… - Pharmacology & …, 2024 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and Multiple sclerosis (MS) …

[HTML][HTML] Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ1-42-induced Alzheimer's disease rat model by activating BDNF/TrkB …

Z Gu, X Lv, Y Guo, M Qi, B Ge - NeuroReport, 2023 - journals.lww.com
Alzheimer's disease (AD) is a degenerative disorder characterized by cognitive dysfunction
and BDNF/TrkB is a well-conceived anti-AD signaling. Cynomorium songaricum Rupr.(C …

Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes

S Dhiman, A Mannan, A Taneja, M Mohan, TG Singh - Life Sciences, 2024 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative condition that primarily affects
motor function and is caused by a gradual decline of dopaminergic neurons in the brain's …

[HTML][HTML] Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving …

P Papadopoulou, A Polissidis, G Kythreoti… - International Journal of …, 2024 - mdpi.com
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic
potential to treat neuroinflammation and cognitive impairment. This review examines the …

[HTML][HTML] Phenolic extract from olive mill wastewater sustains mitochondrial bioenergetics upon oxidative insult

IR Infantino, SAM Cubisino, SC Nibali, P Foti… - Food Chemistry …, 2024 - Elsevier
In the last few years, many efforts have been devoted to the recovery and valorization of
olive oil by-products because of their potentially high biological value. The olive mill …

[HTML][HTML] Costunolide ameliorates rotenone-induced Parkinson's disease in rat model via activation of SIRT-1/p-AMPK cascade and suppression of IL-6/STAT3 axis

A Sirwi, NS El-Sayed, DAI Albadawi, AE Koshak… - Scientific African, 2024 - Elsevier
Costunolide (COST), a sesquiterpene lactone, has demonstrated promising potential in
molecular docking studies targeting key proteins associated with Parkinson's disease (PD) …