Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-
relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal …

Introduction The metabolomics quality assurance and quality control consortium (mQACC)
evolved from the recognized need for a community-wide consensus on improving and …

The first guidance on Good Cell Culture Practice dates back to 2005. This document
expands this to aspects of quality assurance for in vitro cell culture focusing on the …

In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …

Metabolomics, the comprehensive analysis of metabolites in a biological system, provides
detailed information about the biochemical/physiological status of a biological system, and …

Liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) platforms
are widely used to perform high throughput untargeted profiling of biological samples for …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …