Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical
practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic …

New insights into the pathophysiology and natural history of patients with aortic stenosis,
coupled with advances in diagnostic imaging and the dramatic evolution of transcatheter …

Calcific aortic valve disease (CAVD) is highly prevalent and has no pharmaceutical
treatment. Surgical replacement of the aortic valve has proved effective in advanced disease …

Ghali et al Cardiac Actions of IL-33/sST2 819 elevated levels are found in the circulation and
tissues during several inflammatory diseases including rheumatoid arthritis, inflammatory …

Aims Enhanced risk stratification of patients with aortic stenosis (AS) is necessary to identify
patients at high risk for adverse outcomes, and may allow for better management of patient …

Natriuretic peptides have been at the forefront of biomarker use in heart disease and have
been universally recommended as the ideal biomarker in the setting of heart failure. Soluble …

ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane
ST2L isoforms. The ligand of ST2 is IL-33, which determines the activation of numerous …

Aortic valve replacement (AVR) therapy is an obvious choice for symptomatic severe aortic
stenosis (AS) patients as it improves symptoms, left ventricular function, and survival. The …

Introduction and objectives Patients with aortic stenosis (AS) exhibit left ventricular (LV)
remodeling and replacement myocardial fibrosis (RMF). Whether sST2 is associated with …

Background—Recent data suggest that circulating biomarkers may predict outcome in
patients undergoing transcatheter aortic valve replacement (TAVR). We examined the …