[HTML][HTML] Brain-derived neurotrophic factor signaling in depression and antidepressant action

E Castrén, LM Monteggia - Biological psychiatry, 2021 - Elsevier
Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA-and glutamatergic alterations

YT Hu, ZL Tan, D Hirjak, G Northoff - Molecular Psychiatry, 2023 - nature.com
The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …

Alterations in cortical interneurons and cognitive function in schizophrenia

SJ Dienel, DA Lewis - Neurobiology of disease, 2019 - Elsevier
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Brain-derived neurotrophic factor and neuropsychiatric disorders

AE Autry, LM Monteggia, LC Daws - Pharmacological reviews, 2012 - Elsevier
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N= 9484)

ML Molendijk, P Spinhoven, M Polak, BAA Bus… - Molecular …, 2014 - nature.com
Abstract Meta-analyses, published in 2008–2010, have confirmed abnormally low serum
brain-derived neurotrophic factor (BDNF) concentrations in depressed patients and …

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

E Castrén, M Kojima - Neurobiology of disease, 2017 - Elsevier
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Unfolding the role of BDNF as a biomarker for treatment of depression

T Rana, T Behl, A Sehgal, P Srivastava… - Journal of Molecular …, 2021 - Springer
Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …