SigCom LINCS: data and metadata search engine for a million gene expression signatures

JE Evangelista, DJB Clarke, Z Xie… - Nucleic acids …, 2022 - academic.oup.com
Millions of transcriptome samples were generated by the Library of Integrated Network-
based Cellular Signatures (LINCS) program. When these data are processed into …

[HTML][HTML] The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19

J Li, X Kong, T Liu, M Xian… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Angiotensin-converting enzyme 2 (ACE2) has become a hot topic in neuroscience research
in recent years, especially in the context of the global COVID-19 pandemic, where its role in …

Experimental co-infection of calves with SARS-CoV-2 Delta and Omicron variants of concern

K Cool, NN Gaudreault, JD Trujillo… - Emerging Microbes & …, 2024 - Taylor & Francis
Since emerging in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has repeatedly crossed the species barrier with natural infections reported in various …

RummaGEO: automatic mining of human and mouse gene sets from GEO

GB Marino, DJB Clarke, A Lachmann, EZ Deng… - Patterns, 2024 - cell.com
Summary The Gene Expression Omnibus (GEO) has millions of samples from thousands of
studies. While users of GEO can search the metadata describing studies, there is a need for …

Identification of the potential association between SARS-CoV-2 infection and acute kidney injury based on the shared gene signatures and regulatory network

X Zhou, N Wang, W Liu, R Chen, G Yang, H Yu - BMC Infectious Diseases, 2023 - Springer
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
is identified as the cause of coronavirus disease 2019 (COVID-19) pandemic. Acute kidney …

Association of anti-diabetic drugs and COVID-19 outcomes in patients with diabetes mellitus type 2 and cardiomyopathy

J Dimnjaković, T Buble, P Ivanko, I Pristaš… - Scientific Reports, 2024 - nature.com
There is a scarcity of information on the population with diabetes mellitus type 2 and
cardiomyopathy (PDMC) in COVID-19, especially on the association between anti-diabetic …

Deep View of HCC Gene Expression Signatures and Their Comparison with Other Cancers

Y Qian, T Itzel, M Ebert, A Teufel - Cancers, 2022 - mdpi.com
Simple Summary There is a huge gap between the numerous HCC gene signatures and the
fact that no one HCC signature has successfully entered clinical practice. The purpose of …

[HTML][HTML] ACE2 gene polymorphisms are associated with elevated pulmonary artery pressure in congenital heart diseases

Y Zi-Yang, X Nanshan, L Dongling, H Tao, H Yigao… - Gene, 2023 - Elsevier
Backgrounds Angiotensin converting enzyme 2 (ACE2) polymorphisms are related to the
occurrence and prognosis of cardiovascular disease. However, whether ACE2 …

[HTML][HTML] A novel HBc-S230 protein chimeric VLPs induced robust immune responses against SARS-CoV-2

W Feng, Z Chen, L Wu, X Chen, Q Li, Y Xiang… - International …, 2024 - Elsevier
Here, we report that four functional fragments of the Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2) spike protein including receptor binding motif (RBM), fusion …

[HTML][HTML] Unraveling the relevance of SARS-Cov-2 infection and ferroptosis within the heart of COVID-19 patients

AA Saghati, Z Sharifi, M Hatamikhah, M Salimi… - Heliyon, 2024 - cell.com
Background The coronavirus disease 2019 (COVID-19) was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to a huge mortality rate and …