ApoE on high-density lipoproteins is primarily responsible for lipid transport and cholesterol
homeostasis in the central nervous system (CNS). Normally produced mostly by astrocytes …

The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms
(ApoE2, ApoE3, and ApoE4) that differ only by two residues. ApoE4 constitutes the most …

Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …

Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect
vectors separated by hundreds of millions of years of evolutionary history. Entry into …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

INTRODUCTION Antiphospholipid antibodies (aPLs) transiently appear in infectious
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

Although an immense knowledge has accumulated concerning regulation of cholesterol
homeostasis in the body, this does not include the brain, where details are just emerging …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …