Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

X Gao, S Zhang, J Gou, Y Wen, L Fan, J Zhou, G Zhou… - Journal of Infection, 2022 - Elsevier
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious
threat to human health, with patients reportedly suffering from thrombus, vascular injury and …

Protective neutralizing epitopes in SARS‐CoV‐2

H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …

[HTML][HTML] Impact of new variants on SARS-CoV-2 infectivity and neutralization: A molecular assessment of the alterations in the spike-host protein interactions

MH Cheng, JM Krieger, A Banerjee, Y Xiang, B Kaynak… - Iscience, 2022 - cell.com
The emergence of SARS-CoV-2 variants necessitates rational assessment of their impact on
the recognition and neutralization of the virus by the host cell. We present a comparative …

Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies

F Zhang, J Jenkins, RVH de Carvalho… - Nature …, 2023 - nature.com
Human monoclonal antibodies (mAbs) that target the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) spike protein have been isolated from convalescent …

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

J Ou, Y Zhang, Y Wang, Z Zhang, H Wei, J Yu… - Signal transduction and …, 2022 - nature.com
The pandemic of COVID-19 continues worldwide with many variants arising, especially
SARS-CoV-2 Delta (B. 1.617. 2) and Omicron (B. 1.1. 529) variants of concern (VOCs) …

[HTML][HTML] SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

A Onnis, E Andreano, C Cassioli, F Finetti… - Journal of Experimental …, 2022 - rupress.org
CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune
synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape …

Effect of Delta and Omicron mutations on the RBD-SD1 domain of the spike protein in SARS-CoV-2 and the Omicron mutations on RBD-ACE2 interface complex

WY Ching, P Adhikari, B Jawad… - International Journal of …, 2022 - mdpi.com
The receptor-binding domain (RBD) is the essential part in the Spike-protein (S-protein) of
SARS-CoV-2 virus that directly binds to the human ACE2 receptor, making it a key target for …