Photocatalytic late-stage C–H functionalization

P Bellotti, HM Huang, T Faber, F Glorius - Chemical Reviews, 2023 - ACS Publications
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

[HTML][HTML] Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium,(ii) iridium and (iii) organic photoredox agents

JD Bell, JA Murphy - Chemical Society Reviews, 2021 - pubs.rsc.org
Photoredox chemistry with organic or transition metal agents has been reviewed in earlier
years, but such is the pace of progress that we will overlap very little with earlier …

Visible-light-mediated modification and manipulation of biomacromolecules

VM Lechner, M Nappi, PJ Deneny, S Folliet… - Chemical …, 2021 - ACS Publications
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Boron, silicon, nitrogen and sulfur-based contemporary precursors for the generation of alkyl radicals by single electron transfer and their synthetic utilization

V Corcé, C Ollivier, L Fensterbank - Chemical Society Reviews, 2022 - pubs.rsc.org
Recent developments in the use of boron, silicon, nitrogen and sulfur derivatives in single-
electron transfer reactions for the generation of alkyl radicals are described. Photoredox …

Late‐stage C− H Functionalization of Tryptophan‐Containing Peptides with Thianthrenium Salts: Conjugation and Ligation

N Kaplaneris, A Puet, F Kallert… - Angewandte Chemie …, 2023 - Wiley Online Library
Bioorthogonal late‐stage diversification of structurally complex peptides bears enormous
potential for drug discovery and molecular imaging, among other applications. Herein, we …

Recent Advances in Electron Donor‐Acceptor (EDA)‐Complex Reactions involving Quaternary Pyridinium Derivatives

B Saxena, RI Patel, A Sharma - Advanced Synthesis & …, 2023 - Wiley Online Library
Quaternary pyridinium compounds are valuable intermediates in organic synthesis, which
have gained immense popularity in the synthetic community. The application of transition …

Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation

S Krajcovicova, DR Spring - Angewandte Chemie International …, 2023 - Wiley Online Library
Peptide stapling is a robust strategy for generating enzymatically stable, macrocyclic
peptides. The incorporation of biologically relevant tags (such as cell‐penetrating motifs or …

Radical C–H Sulfonation of Arenes: Its Applications on Bioactive and DNA-Encoded Molecules

Y Zhang, S Xia, W Shi, B Lin, X Su, W Lu, X Wu… - Organic …, 2022 - ACS Publications
The photocatalyst-free electron donor–acceptor (EDA) complex photochemistry was
deemed to expand the potential of photodriven radical chemistry. Here, we report a cross …

Catalyst-Free C(sp2)-H Borylation through Aryl Radical Generation from Thiophenium Salts via Electron Donor–Acceptor Complex Formation

B Li, K Wang, H Yue, A Drichel, J Lin, Z Su… - Organic …, 2022 - ACS Publications
Aryl borates lie at the heart of carbon–carbon bond couplings, and they are widely applied to
the synthesis of functional materials, pharmaceutical compounds, and natural products …

Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan

JC Lee, JD Cuthbertson, NJ Mitchell - Organic Letters, 2023 - ACS Publications
Across eukaryotic proteomes, tryptophan is the least abundant of the 20 canonical amino
acids, which makes it an ideal chemical handle for the late-stage functionalization of peptide …