Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

Stem cells are a unique source of self-renewing cells within the human body. Before the end
of the last millennium, adult stem cells, in contrast to their embryonic counterparts, were …

Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are in a
high-flux metabolic state, with a high dependence on threonine catabolism. However, little is …

There exists a worldwide shortage of donor livers available for orthotropic liver
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic …

How are closely related lineages, including liver, pancreas, and intestines, diversified from a
common endodermal origin? Here, we apply principles learned from developmental biology …

The availability of pluripotent stem cells offers the possibility of using such cells to model
hepatic disease and development. With this in mind, we previously established a protocol …

Background/Aims Chronic liver disease is a major widespread cause of death, and whole
liver transplantation is the only definitive treatment for patients with end-stage liver diseases …

The use of novel drugs and chemicals requires reliable data on their potential toxic effects
on humans. Current test systems are mainly based on animals or in vitro–cultured animal …

Human embryonic stem cells (hESCs) are routinely cultured on fibroblast feeder layers or in
fibroblast-conditioned medium, which requires continued supply of feeder cells and poses …

INTRODUCTION: Mesenchymal stem cells display extensive proliferative capacity of
multilineage differentiation. The stromal compartment of mesenchymal tissues is considered …