The neuroanatomical–functional paradox in spinal cord injury

K Fouad, PG Popovich, MA Kopp… - Nature Reviews …, 2021 - nature.com
Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis

MD Budde, M Xie, AH Cross, SK Song - Journal of Neuroscience, 2009 - Soc Neuroscience
The dissociation between magnetic resonance imaging (MRI) and permanent disability in
multiple sclerosis (MS), termed the clinicoradiological paradox, can primarily be attributed to …

[图书][B] Brain arousal and information theory: neural and genetic mechanisms

DW Pfaff - 2006 - degruyter.com
Pfaff presents a daring perspective on the long-standing puzzle of what arousal is. He
argues that, beneath our mental functions and emotional dispositions, a primitive neuronal …

Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury

KA Kigerl, W Lai, S Rivest, RP Hart… - Journal of …, 2007 - Wiley Online Library
Activation of macrophages via toll‐like receptors (TLRs) is important for inflammation and
host defense against pathogens. Recent data suggest that non‐pathogenic molecules …

Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinalcord injury

Q Cao, Q He, Y Wang, X Cheng… - Journal of …, 2010 - Soc Neuroscience
Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We
explored whether the combination of neurotrophic factors and transplantation of adult rat …

Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells

Q Cao, XM Xu, WH DeVries, GU Enzmann… - Journal of …, 2005 - Soc Neuroscience
Demyelination contributes to the physiological and behavioral deficits after contusive spinal
cord injury (SCI). Therefore, remyelination may be an important strategy to facilitate repair …

Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?

N Pukos, MT Goodus, FR Sahinkaya, DM McTigue - Glia, 2019 - Wiley Online Library
Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year,
resulting in sudden motor, sensory and autonomic impairments below the level of injury …

Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury

BC Hains, JA Black, SG Waxman - Journal of Comparative …, 2003 - Wiley Online Library
Spinal cord injury (SCI) results in loss of voluntary motor control followed by incomplete
recovery, which is partly mediated by the descending corticospinal tract (CST). This system …

[HTML][HTML] Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it

SM Onifer, GM Smith, K Fouad - Neurotherapeutics, 2011 - Elsevier
Motor, sensory, and autonomic functions can spontaneously return or recover to varying
extents in both humans and animals, regardless of the traumatic spinal cord injury (SCI) …