UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

At a population level, there is growing evidence of the beneficial effects of dietary flavonoids
on health. However, there is extensive heterogeneity in the response to increased intake …

Using online surveys, we collected data regarding COVID-19-related loss of smell or taste
from 69,841 individuals. We performed a multi-ancestry genome-wide association study and …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

Saponins are bioactive compounds generally considered to be produced by plants to
counteract pathogens and herbivores. Besides their role in plant defense, saponins are of …

Background. Phase II biotransformation reactions (also 'conjugation reactions') generally
serve as a detoxifying step in drug metabolism. Phase II drug metabolising enzymes are …

Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

Understanding the diversity of insect responses to chemical pressures (eg plant
allelochemicals and pesticides) in their local ecological context represents a key challenge …

The overall fate or disposition of a xenobiotic, which encompasses its absorption,
distribution, metabolism, and elimination or ADME, is determined by three major factors …