Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Atherosclerosis is a chronic inflammatory vascular disease and the predominant cause of
heart attack and ischemic stroke. Despite the well-known sexual dimorphism in the …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in
the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Lipoproteins and Atherosclerosis Christopher K. Glass*†‡ and Joseph L. Witztum*
Specialized Center of Research on Molecular Serum cholesterol is carried by several …