Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes

J Zimmermann, E Werner, S Sodei… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus Famously found written on the blackboard of physicist Richard Feynman after
his death was the phrase,“What I cannot create, I do not understand.” From this perspective …

The protometabolic nature of prebiotic chemistry

N Nogal, M Sanz-Sánchez, S Vela-Gallego… - Chemical Society …, 2023 - pubs.rsc.org
The field of prebiotic chemistry has been dedicated over decades to finding abiotic routes
towards the molecular components of life. There is nowadays a handful of prebiotically …

A Multifunctional Amino Acid Enables Direct Recycling of Spent LiFePO4 Cathode Material

D Tang, G Ji, J Wang, Z Liang, W Chen, H Ji… - Advanced …, 2024 - Wiley Online Library
Lithium iron phosphate (LiFePO4, LFP) batteries are extensively used in electric vehicles
and energy storage due to their good cycling stability and safety. However, the finite service …

Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation

M Brabender, DP Henriques Pereira… - Proceedings of the …, 2024 - National Acad Sciences
Autotrophic theories for the origin of metabolism posit that the first cells satisfied their carbon
needs from CO2 and were chemolithoautotrophs that obtained their energy and electrons …

Metal ions turn on a stereoselective nonenzymatic reduction of keto acids by the coenzyme NADH

RJ Mayer, J Moran - Chem, 2024 - cell.com
The relationship between genetic molecules and metabolism is one of the longest-standing
problems for the origin of life. A central molecule within early metabolism is the coenzyme …

Quantifying reductive amination in nonenzymatic amino acid synthesis

RJ Mayer, J Moran - Angewandte Chemie International Edition, 2022 - Wiley Online Library
Amino acid biosynthesis initiates with the reductive amination of α‐ketoglutarate with
ammonia to produce glutamate. However, the other α‐keto acids derived from the glyoxylate …

Transcriptomics and metabolomics reveal improved performance of Hu sheep on hybridization with Southdown sheep

L Kong, Y Yue, J Li, B Yang, B Chen, J Liu… - Food Research …, 2023 - Elsevier
Consumers are increasingly demanding high-quality mutton. Cross breeding can improve
meat quality and is widely used in sheep breeding. However, little is known about the …

Prebiotic synthesis of aspartate using life's metabolism as a guide

SA Harrison, WL Webb, H Rammu, N Lane - Life, 2023 - mdpi.com
A protometabolic approach to the origins of life assumes that the conserved biochemistry of
metabolism has direct continuity with prebiotic chemistry. One of the most important amino …

NADH-mediated primordial synthesis of amino acids

N Nogal, J Luis-Barrera, S Vela-Gallego… - Organic Chemistry …, 2024 - pubs.rsc.org
The pathways that could explain the abiotic synthesis of amino acids are different from those
observed in living organisms, which leaves a gap of knowledge between bottom-up …

Biophysical interactions underpin the emergence of information in the genetic code

A Halpern, LR Bartsch, K Ibrahim, SA Harrison, M Ahn… - Life, 2023 - mdpi.com
The genetic code conceals a 'code within the codons', which hints at biophysical interactions
between amino acids and their cognate nucleotides. Yet, research over decades has failed …