Soluble biomarkers of cognition and depression in adults with HIV infection in the combination therapy era

AM Anderson, Q Ma, SL Letendre, J Iudicello - Current HIV/AIDS Reports, 2021 - Springer
Abstract Purpose of Review Cognitive impairment and depression continue to be common
among people with HIV (PWH) in the combination antiretroviral therapy (ART) era. A better …

HIV-1 subtype C Vpr amino acid residue 45Y and specific conserved fragments are associated with neurocognitive impairment and markers of viral load

V Ruhanya, GB Jacobs, RH Paul, JA Joska… - AIDS Research and …, 2023 - liebertpub.com
There is increasing evidence that HIV-1 viral protein R (Vpr) plays an important role in the
pathogenesis of cognitive impairment. We investigated the relationship between HIV-1 …

HIV-1 subtype C Tat exon-1 amino acid residue 24K is a signature for neurocognitive impairment

V Ruhanya, GB Jacobs, RH Paul, JA Joska… - Journal of …, 2022 - Springer
Variation and differential selection pressures on Tat genes have been shown to alter the
biological function of the protein, resulting in pathological consequences in a number of …

Plasma cytokine levels as predictors of global and domain-specific human immunodeficiency virus-associated neurocognitive impairment in treatment-Naive …

V Ruhanya, GB Jacobs, R Paul, J Joska… - Journal of Interferon & …, 2021 - liebertpub.com
Central nervous system dysfunction, associated with human immunodeficiency virus (HIV)
infection, remains a significant clinical concern, affecting at least 50% of infected people …

HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine

HR Kondur, TK Lee, R McIntosh, H Gouse, R Paul… - Journal of …, 2022 - Springer
Although co-occurring methamphetamine (meth) use and HIV amplify the risk for
neuropsychiatric comorbidities, the underlying neuroimmune mechanisms are not well …

Plasma Cytokine Biomarker Cutoff Values for HIV-Associated Neurocognitive Impairment in Adults

V Ruhanya, GB Jacobs, RH Paul, JA Joska… - Viral …, 2021 - liebertpub.com
Diagnosing HIV-associated neurocognitive impairment in most high-burden, but resource-
constrained, settings is difficult due to the unavailability of specialist neurologists and …

Proinflammatory cytokines and chemokines are related to MRI measures of white and gray matter in HIV infection

V Ruhanya, GB Jacobs, R Paul, J Joska, S Seedat… - 2021 - preprints.org
Background: HIV is accompanied by production of proinflammatory cytokines which are
regarded as critical in neuronal damage, leading to brain dysfunction, hence the need to …