Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …

Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …

Myeloid cell leukemia‐1 (MCL1), an antiapoptotic member of the BCL2 family characterized
by a short half‐life, functions as a rapid sensor that regulates cell death and other relevant …

How intracellular bacteria subvert the major histocompatibility complex (MHC) class I
pathway is poorly understood. Here, we show that the obligate intracellular bacterium …

As a tripartite cell death switch, B-cell lymphoma protein 2 (Bcl-2) family members precisely
regulate the endogenous apoptosis pathway in response to various cell signal stresses …

Apoptosis is a mechanism of programmed cell death crucial in organism development,
maintenance of tissue homeostasis, and several pathogenic processes. The B cell …

The maturation of RNA from its nascent transcription to ultimate utilization (eg, translation,
miR-mediated RNA silencing, etc.) involves an intricately coordinated series of biochemical …

Alternative polyadenylation in the 3′ UTR (3′ UTR-APA) is a mode of gene expression
regulation, fundamental for mRNA stability, translation and localization. In the immune …

B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2
family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) …

Intracranial aneurysm (IA) is a pathological dilation of the cerebral arteries. Vascular smooth
muscle cell (VSMC) dysfunction assumes a role in IA development. In this context, this study …