The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Utilization of polymers as biomaterials has greatly impacted the advancement of modern
medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant …

Strategies for bone tissue regeneration have been continuously evolving for the last 25
years since the introduction of the “tissue engineering” concept. The convergence of the life …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …

Extracellular matrix (ECM) is a complex cellular environment consisting of proteins,
proteoglycans, and other soluble molecules. ECM provides structural support to mammalian …

Three-dimensional (3D) printing techniques for scaffold fabrication have shown promising
advancements in recent years owing to the ability of the latest high-performance printers to …

The incorporation of bioactive glass into bone tissue-engineered scaffolds can be widely
beneficial based on emerging evidence in the literature about the angiogenic potential of …

Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with
osteoinductive potential have emerged. Over the last 50 years, however, our ability to …

Macroscale drug delivery (MDD) devices are engineered to exert spatiotemporal control
over the presentation of a wide range of bioactive agents, including small molecules …