[HTML][HTML] Ionotropic gelation and chemical crosslinking as methods for fabrication of modified-release gellan gum-based drug delivery systems

P Gadziński, A Froelich, B Jadach, M Wojtyłko… - Pharmaceutics, 2023 - mdpi.com
Hydrogels have a tridimensional structure. They have the ability to absorb a significant
amount of water or other natural or simulated fluids that cause their swelling albeit without …

Biological role of gellan gum in improving scaffold drug delivery, cell adhesion properties for tissue engineering applications

T Muthukumar, JE Song, G Khang - Molecules, 2019 - mdpi.com
Over the past few decades, gellan gum (GG) has attracted substantial research interest in
several fields including biomedical and clinical applications. The GG has highly versatile …

Gellan gum in drug delivery applications

M Milivojevic, I Pajic-Lijakovic, B Bugarski… - … polysaccharides in drug …, 2019 - Elsevier
The different techniques that enable drug delivery in the desired manner are constantly
investigated and developed to enhance patient compliance and drug efficiency and to …

Natural polysaccharides and proteins applied to the development of gastroresistant multiparticulate systems for anti-inflammatory drug delivery–a systematic review

WT Vieira, MVS Nicollini, MGC da Silva… - European Polymer …, 2022 - Elsevier
Multiparticulate drug delivery systems (MDDSs) are attracting growing interest due to their
therapeutic benefits and technological advantages. This system usually requires lower …

Fabrication methods and form factors of gellan gum-based materials for drug delivery and anti-cancer applications

C Villarreal-Otalvaro, JM Coburn - ACS Biomaterials Science & …, 2021 - ACS Publications
Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main
challenges of cancer treatment. Exploration of drug delivery methods is a growing field of …

Concentration-dependent rheological behavior and gelation mechanism of high acyl gellan aqueous solutions

X Yang, Y Hou, T Gong, L Sun, J Xue, Y Guo - International journal of …, 2019 - Elsevier
In this study, the rheological properties and gelation mechanism of high acyl gellan (HAG)
were investigated. The critical overlap concentration (C⁎) of HAG was determined to be …

Mefenamic acid modified-release by encapsulation in a k-carrageenan/sericin blend

MVS Nicolini, WT Vieira, MGC da Silva… - Journal of Industrial and …, 2023 - Elsevier
Multiple dosages of mefenamic acid have been reported to result in side effects such as
gastrointestinal discomfort, headaches and fatigue. Therefore, a modified release system for …

Formulation and characterization of ionically crosslinked gellan gum hydrogels using trilysine at low temperatures for antibody delivery

C Villarreal-Otalvaro, S Gupta, RW Dorn… - Colloids and Surfaces B …, 2024 - Elsevier
Research of the nontraditional polysaccharide gellan gum (GG) is a growing space for the
development of novel drug delivery systems due to its tunable physic-mechanical properties …

κ-Carrageenan/sericin polymer matrix modified with different crosslinking agents and thermal crosslinking: Improved release profile of mefenamic acid

WT Vieira, MVS Nicolini, MGC da Silva… - International Journal of …, 2024 - Elsevier
The crosslinking of the polymer matrix with compatible macromolecules results in a three-
dimensional network structure that offers an enhancement in the controlled release …

Recent opportunities and application of gellan gum based drug delivery system for intranasal route

A Garg, K Lavania - DARU Journal of Pharmaceutical Sciences, 2024 - Springer
Objectives In the recent years, in-situ hydrogel based on gellan gum has been investigated
for delivery of various drug molecules particularly to treat neurological disorders via …