Vulnerable atherosclerotic plaques with hemorrhage considerably contribute to
cardiovascular morbidity and mortality. Calcification is the main characteristic of advanced …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Endothelial cells (ECs) are an important cell type typically affected in sepsis …

Following an intraventricular hemorrhage (IVH), red blood cell lysis and hemoglobin (Hb)
oxidation with the release of heme can cause sterile neuroinflammation. In this study, we …

Neovascularization is implicated in the pathology of retinopathy of prematurity (ROP),
diabetic retinopathy (DR), and age-related macular degeneration (AMD), which are the …

Grass carp hemorrhagic disease is a significant problem in grass carp aquaculture. It
releases highly oxidizing hemoglobin (Hb) into tissues, induces rapid autooxidation, and …

Accumulation of hemin in cells, tissues, and organs is one of the major pathological
conditions linked to hemolytic diseases like malaria. Pro-oxidant hemin confers high toxicity …

Hemolysis in red blood cells followed by hemoglobin degradation results in high hemin
levels in the systemic circulation. Such a level of hemin is disastrous for cells and tissues …

Objective This study aimed to construct a predictive model for assessing the risk of
development of neuropsychiatric systemic lupus erythematosus (NPSLE) among patients …

Hemin, a byproduct of hemoglobin degradation, inflicts oxidative insult to cells. Following its
accumulation, several proteins are recruited for heme detoxification with heme oxygenase …

We previously demonstrated that reduced intrinsic electron transport chain (ETC) activity
predicts and promotes sensitivity to the BCL-2 antagonist, venetoclax (Ven) in multiple …