In most organisms, the whole genome is maintained throughout the life span. However,
exceptions occur in some species where the genome is reduced during development …

Rapid advancement in high-throughput sequencing and analytical approaches has seen a
steady increase in the generation of genomic resources for helminth parasites. Now …

Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues.
Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and …

Programmed DNA loss is a gene silencing mechanism that is employed by several
vertebrate and nonvertebrate lineages, including all living jawless vertebrates and …

Genome stability is a crucial feature of eukaryotic organisms because its alteration
drastically affects the normal development and survival of cells and the organism as a …

In some eukaryotes, germline and somatic genomes differ dramatically in their composition.
Here we characterise a major germline–soma dissimilarity caused by a germline-restricted …

The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

Over the last few decades, an increasing number of vertebrate taxa have been identified that
undergo programmed genome rearrangement, or programmed DNA loss, during …

Some species undergo programmed DNA elimination (PDE), whereby portions of the
genome are systematically destroyed in somatic cells. PDE has emerged independently in …

Germline and somatic genomes are in general the same in a multicellular organism.
However, programmed DNA elimination leads to a reduced somatic genome compared to …