The characterization of soft tissues remains a vital need for various bioengineering and
medical fields. Developing areas such as regenerative medicine, robot-aided surgery, and …

Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing
dysfunctional ECM could potentially prevent age-related pathologies. Interventions …

Quantitative micromechanical characterization of single cells and multicellular tissues or
organisms is of fundamental importance to the study of cellular growth, morphogenesis, and …

Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

Apical extracellular matrices (aECMs) coat exposed surfaces of epithelia to shape
developing tissues and protect them from environmental insults. Despite their widespread …

Abstract Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous
species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor …

Apical extracellular matrices (aECMs) form a physical barrier to the environment. In
Caenorhabditis elegans, the epidermal aECM, the cuticle, is composed mainly of different …

ABSTRACT A characteristic of normal aging and age-related diseases is the remodeling of
the cellular organization of a tissue through polyploid cell growth. Polyploidy arises from an …

Human centenarians and longevity mutants of model organisms show lower incidence rates
of late-life morbidities than the average population. However, whether longevity is caused by …