Chronic stress contributes to the onset of type 2 diabetes (T2D), yet the underlying
etiological mechanisms are not fully understood. Responses to stress are influenced by …

The circadian clock regulates many key physiological processes such as the sleep–wake
cycle, hormone release, cardiovascular health, glucose metabolism and body temperature …

Mild hypercortisolism is defined as biochemical evidence of abnormal cortisol secretion
without the classical detectable manifestations of overt Cushing's syndrome and, above all …

Objective Cushing's syndrome is characterized by high morbidity and mortality with high
interindividual variability. Easily measurable biomarkers, in addition to the hormone assays …

Background: Exposure to adversity in utero is thought to increase susceptibility to develop
posttraumatic stress disorder (PTSD) following later life trauma, due to neurobiological …

For the intensive care professional who cares for abdominal organ transplant recipients, a
foundational knowledge of the core principles of immunosuppression management is …

Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response,
and it is also noteworthy that these steroidal molecules present potent anti-inflammatory …

Objective Psychosocial stress is transduced into disease risk through energy-dependent
release of hormones from the HPA and SAM axes. The levels of glucocorticoid and …

The regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with
polymorphisms and the methylation degree of the glucocorticoid receptor gene (NR3C1) …

Methods We summarized the isoforms of GRs and the mechanisms involved in CRPC. An
updated literature search was performed from the ClinicalTrials database, the National …