Biochemical and biological attributes of matrix metalloproteinases
N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
Vascular tissue engineering: challenges and requirements for an ideal large scale blood vessel
CD Devillard, CA Marquette - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension
F Perros, D Montani, P Dorfmüller… - American journal of …, 2008 - atsjournals.org
Rationale: Platelet-derived growth factor (PDGF) promotes the proliferation and migration of
pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of …
pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
Smooth muscle cells in atherosclerosis originate from the local vessel wall and not circulating progenitor cells in ApoE knockout mice
JF Bentzon, C Weile, CS Sondergaard… - … , and vascular biology, 2006 - Am Heart Assoc
Objective—Recent studies of bone marrow (BM)-transplanted apoE knockout (apoE−/−)
mice have concluded that a substantial fraction of smooth muscle cells (SMCs) in …
mice have concluded that a substantial fraction of smooth muscle cells (SMCs) in …
Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein …
Objectives: The aim of this study was to assess the influence of pro-inflammatory interleukin
(IL)-1 genotype status on the risk for coronary artery disease (CAD), defined as> 50 …
(IL)-1 genotype status on the risk for coronary artery disease (CAD), defined as> 50 …
Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease
Background Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular
cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover …
cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover …
Invited review: Vascular cells contribute to atherosclerosis by cytokine-and innate-immunity-related inflammatory mechanisms
H Loppnow, K Werdan, M Buerke - Innate immunity, 2008 - journals.sagepub.com
Cardiovascular diseases are the human diseases with the highest death rate and
atherosclerosis is one of the major underlying causes of cardiovascular diseases …
atherosclerosis is one of the major underlying causes of cardiovascular diseases …
A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease
T Szasz, K Thakali, GD Fink… - … Biology and Medicine, 2007 - journals.sagepub.com
Reactive oxygen species (ROS) are by-products of oxygen metabolism, normally present in
low levels inside cells, where they participate in signaling processes. The delicate balance …
low levels inside cells, where they participate in signaling processes. The delicate balance …