Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …
Central dogma rates and the trade-off between precision and economy in gene expression
Steady-state protein abundance is set by four rates: transcription, translation, mRNA decay
and protein decay. A given protein abundance can be obtained from infinitely many …
and protein decay. A given protein abundance can be obtained from infinitely many …
Spliceosomal introns: features, functions, and evolution
IV Poverennaya, MA Roytberg - Biochemistry (Moscow), 2020 - Springer
Spliceosomal introns, which have been found in most eukaryotic genes, are non-coding
sequences excised from pre-mRNAs by a special complex called spliceosome during …
sequences excised from pre-mRNAs by a special complex called spliceosome during …
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its
disturbance is implicated in metabolic diseases. Using an engineered sensor that activates …
disturbance is implicated in metabolic diseases. Using an engineered sensor that activates …
Global proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms
Cellular stress responses often require transcription-based activation of gene expression to
promote cellular adaptation. Whether general mechanisms exist for stress-responsive gene …
promote cellular adaptation. Whether general mechanisms exist for stress-responsive gene …
Divergence and Conservation of the Major UPR Branch IRE1-bZIP Signaling Pathway across Eukaryotes
The unfolded protein response (UPR) is crucial to life by regulating the cellular response to
the stress in the endoplasmic reticulum (ER) imposed by abiotic and biotic cues such as …
the stress in the endoplasmic reticulum (ER) imposed by abiotic and biotic cues such as …
Fundamental and Applicative Aspects of the Unfolded Protein Response in Yeasts
Y Ishiwata-Kimata, Y Kimata - Journal of Fungi, 2023 - mdpi.com
Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER
stress, eukaryotic cells commonly provoke a protective gene expression program called the …
stress, eukaryotic cells commonly provoke a protective gene expression program called the …
The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA
R Di Santo, S Aboulhouda, DE Weinberg - Elife, 2016 - elifesciences.org
HAC1 encodes a transcription factor that is the central effector of the unfolded protein
response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an …
response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an …
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon
ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during …
ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during …
Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae
X Xia - International journal of molecular sciences, 2019 - mdpi.com
Hac1p is a key transcription factor regulating the unfolded protein response (UPR) induced
by abnormal accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) …
by abnormal accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) …