Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1

Z Feng, ME Hom, TE Bearrood, ZC Rosenthal… - Nature chemical …, 2022 - nature.com
Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms
are required for the survival of stem-like tumor cells. We have discovered selective inhibitors …

Fluorescent heterocycles: Recent trends and new developments

S Schramm, D Weiss - Advances in Heterocyclic Chemistry, 2019 - Elsevier
Over the last two decades fluorescent materials have strongly influenced the technological
development of modern societies. Ranging from organic photovoltaic to OLED TVs, from …

Photophysics of Ruthenium (II) Complexes with Thiazole π-Extended Dipyridophenazine Ligands

M Kaufmann, C Müller, AA Cullen… - Inorganic …, 2020 - ACS Publications
Transition-metal-based donor–acceptor systems can produce long-lived excited charge-
transfer states by visible-light irradiation. The novel ruthenium (II) polypyridyl type complexes …

5-N-Arylaminothiazoles as highly twisted fluorescent monocyclic heterocycles: synthesis and characterization

K Yamaguchi, T Murai, S Hasegawa… - The Journal of …, 2015 - ACS Publications
A series of 5-N-arylaminothiazoles was prepared by reacting thioamide dianions derived
from secondary thioamides with thioformamides, followed by sequential oxidation with …

Tuning the polarity and surface activity of hydroxythiazoles–extending the applicability of highly fluorescent self-assembling chromophores to supra-molecular …

SH Habenicht, S Schramm, S Fischer… - Journal of Materials …, 2016 - pubs.rsc.org
A small library of N, N-diethyl-and-diethanolsulfonamides of differently substituted 2-(2-
pyridyl)-and 2-pyrazinyl-4-alkoxythiazoles has been synthesized and investigated in terms …

Strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine

MZC Hatit, CP Seath, AJB Watson… - The Journal of Organic …, 2017 - ACS Publications
A method for conditional control of orthogonal sequential Cu-catalyzed azide− alkyne
cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine …

Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices

K Godugu, S Shaik, MKM Pinjari, TR Gundala… - Dyes and …, 2021 - Elsevier
A facile and more efficient solvent-free mechanochemical synthetic route has been
developed for the synthesis of a series of solid state white light emissive thiazole-based …

Synthesis and Photophysical Properties of 5-N-Arylamino-4-methylthiazoles Obtained from Direct C–H Arylations and Buchwald–Hartwig Aminations of 4 …

T Murai, K Yamaguchi, T Hayano, T Maruyama… - …, 2017 - ACS Publications
5-N-Arylamino-4-methylthiazoles were synthesized from commercially available 4-
methylthiazole in three consecutive steps:(i) direct Pd-catalyzed C–H arylations of the …

Assembly of T-shaped amphiphilic thiazoles on the air–water interface: impact of polar chromophore moieties, as well as dipolarity and π-extension of the …

ML Hupfer, M Kaufmann, J Preiß, D Weiß, R Beckert… - Langmuir, 2019 - ACS Publications
The supramolecular structure essentially determines the properties of organic thin films. In
this work, we systematically investigate the influence of the chromophore on the …

Synthesis of thiazoles bearing aryl enamine/aza‐enamine side chains: effect of the π‐conjugated spacer structure and hydrogen bonding on photophysical properties

KI Lugovik, AV Popova, AK Eltyshev… - European Journal of …, 2017 - Wiley Online Library
An efficient synthesis of a new series of di‐and trisubstituted thiazoles (TZs) bearing aryl
enamine side‐chains (ETZs) has been developed and the optical properties of these …