APP function and lipids: a bidirectional link

MOW Grimm, J Mett, HS Grimm… - Frontiers in molecular …, 2017 - frontiersin.org
Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of
the major histopathological hallmarks of Alzheimer's disease (AD), a progressive …

Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis

M Maulik, D Westaway, JH Jhamandas, S Kar - Molecular neurobiology, 2013 - Springer
Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder believed to
be initiated by accumulation of amyloid β (Aβ)-related peptides derived from proteolytic …

Modulatory role of simvastatin against aluminium chloride‐induced behavioural and biochemical changes in rats

M Nampoothiri, J John, N Kumar, J Mudgal… - Behavioural …, 2015 - Wiley Online Library
Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the
pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral …

The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease

MOW Grimm, VC Zimmer, J Lehmann… - BioMed research …, 2013 - Wiley Online Library
Alzheimer's disease (AD) is a devastating neurodegenerative disorder currently affecting
over 35 million people worldwide. Pathological hallmarks of AD are massive amyloidosis …

The role of cholesterol metabolism in Alzheimer's disease

JH Sun, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Alzheimer's disease (AD) is the most common type of dementias and becoming a worldwide
problem. As the time goes by, more and more researches show that AD is related to …

Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ1–42 Involving Modulation of TLR4/TRAF6/NF-κB Pathway

S Wang, X Zhang, L Zhai, X Sheng, W Zheng… - Journal of Molecular …, 2018 - Springer
Inflammatory damage aggravates the progression of Alzheimer's disease (AD) and the
mechanism of inflammatory damage may provide a new therapeutic window for the …

Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction

DA Ghareeb, HS Hafez, HM Hussien… - Metabolic brain disease, 2011 - Springer
In the present study we investigated the effect of the non-alcoholic fatty liver disease
(NAFLD) on the alterations in the activity of neurotransmitters catabolizing enzymes and …

Statins modify the response of chicks to challenges with xylazine-ketamine and carbaryl

HM Rashid, FK Mohammad - Veterinarski arhiv, 2023 - hrcak.srce.hr
Sažetak Statins are known to affect brain function in a manner not related to their
dyslipidemic effects. The purpose of the present study was to assess the behavioral …

Differential effects of statins on plasma and brain cholinesterase activities in chicks

HM Rashid, FK Mohammad - Neuroscience Research Notes, 2023 - neuroscirn.org
Statins used to treat dyslipidemia may differentially modulate cholinesterase (ChE) activity
impacting neuronal function. This study examines the effects of three statins (atorvastatin …

[HTML][HTML] Adverse neurobehavioral changes with reduced blood and brain cholinesterase activities in mice treated with statins

RF Al-Shalchi, FK Mohammad - Veterinary World, 2024 - ncbi.nlm.nih.gov
Materials and Methods: Two hours after vehicle (control) or statin dosing at 250, 500, 750, or
1000 mg/kg orally, each mouse was subjected to 5 min open-field activity, negative geotaxis …