Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Interleukin 6 as an energy allocator in muscle tissue

TM Kistner, BK Pedersen, DE Lieberman - Nature metabolism, 2022 - nature.com
Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Regulation of adipose tissue inflammation by interleukin 6

MS Han, A White, RJ Perry… - Proceedings of the …, 2020 - National Acad Sciences
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue
infiltration by immune cells and increased expression of inflammatory cytokines. It is …

Role of interleukin-6 in vascular health and disease

P Villar-Fincheira, F Sanhueza-Olivares… - Frontiers in molecular …, 2021 - frontiersin.org
IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

The controversial role of IL-6 in adipose tissue on obesity-induced dysregulation of glucose metabolism

S Wueest, D Konrad - American Journal of Physiology …, 2020 - journals.physiology.org
Interleukin (IL)-6 is a pleotropic cytokine with various physiological and pathophysiological
functions in different cells and tissues. In cells residing within white adipose tissue, several …

Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions

L Della Guardia, R Codella - Cytokine & Growth Factor Reviews, 2021 - Elsevier
Metabolic conditions share a common low-grade inflammatory milieu, which represents a
key-factor for their ignition and maintenance. Exercise is instrumental for warranting …

The pathophysiology of MASLD: an immunometabolic perspective

J Schwärzler, F Grabherr, C Grander… - Expert review of …, 2024 - Taylor & Francis
Introduction Metabolic-associated liver diseases have emerged pandemically across the
globe and are clinically related to metabolic disorders such as obesity and type 2 diabetes …

The involvement of glucose and lipid metabolism alteration in rheumatoid arthritis and its clinical implication

TT Luo, YJ Wu, Q Yin, WG Chen… - Journal of Inflammation …, 2023 - Taylor & Francis
Obviously, immune cells like T cells and macrophages play a major role in rheumatoid
arthritis (RA). On one hand, the breakdown of immune homeostasis directly induces …

JNK signaling pathway in metabolic disorders: An emerging therapeutic target

R Garg, S Kumariya, R Katekar, S Verma… - European Journal of …, 2021 - Elsevier
Metabolic Syndrome is a multifactorial disease associated with increased risk of
cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc. Various stress …

Unravelling the broader complexity of IL-6 involvement in health and disease

RH Jenkins, STO Hughes, AC Figueras, SA Jones - Cytokine, 2021 - Elsevier
The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the
biological impact of this cytokine in health and disease. With broad activities affecting the …