After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

The central nervous system responds to diverse neurologic injuries with a vigorous
activation of astrocytes. While this phenomenon is found in many different species, its …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Optic nerve transection in adult rats results in the death of approximately 50% of the
axotomized retinal ganglion cells (RGCs) by 1 week and nearly 90% by 2 weeks after injury …

In the past decade, considerable progress has been made in the understanding of the
biology of rodent oligodendrocyte precursor cells and their role in the generation of …

Local spinal cord lesions are often greatly enlarged by secondary damage, a process which
leads to massive additional cell death. This process is poorly understood. In order to …

Neuronal regeneration does generally not occur in the central nervous system (CNS) after
injury, which has been attributed to the generation of glial scar tissue. In this report we show …

Estrogens and androgens can protect neurons from death caused by injury to the central
nervous system. Astrocytes and microglia are major players in events triggered by neural …

In the central nervous system (CNS), nerve regeneration after traumatic injury fails. The
formation of a dense fibrous scar is thought to restrict in part the growth of axonal …