One of the most consistent genetic findings to have emerged from bipolar disorder genome
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …

Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention
in recent years since the discovery that it acts as a potent signaling molecule with wide …

After decades of research, the mechanism of action of lithium in preventing recurrences of
bipolar disorder remains only partially understood. Lithium research is complicated by the …

Although the involvement of genomic factors in bipolar disorder is evident, there are still
many unclear points about its pathophysiology. We proposed the mitochondrial dysfunction …

Although mood disorders have traditionally been regarded as good prognosis diseases, a
growing body of data suggests that the long-term outcome for many patients is often much …

This is a review of the studies comparing unipolar and bipolar depression, with focus on the
course, symptomatology, neurobiology, and psychosocial literatures. These are reviewed …

Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes
of mania and depression. More than half of BD patients are non-responsive to lithium, the …

The search for genes in bipolar disorder has provided numerous genetic loci that have been
linked to susceptibility to developing the disorder. However, because of the genetic …

To search DNA methylation difference between monozygotic twins discordant for bipolar
disorder, we applied a comprehensive genome scan method, methylation-sensitive …

Clinical studies over the years have provided evidence that monoamine signaling and
hypothalamic-pituitary-adrenal axis disruption are integral to the pathophysiology of bipolar …