HDL functionality

H Soran, S Hama, R Yadav… - Current opinion in …, 2012 - journals.lww.com
HDL has a wide range of functions some of which are independent of its cholesterol content.
Its cargo of apolipoproteins, various proteins and phospholipids contributes most to its …

Expanding the Clinical Indications for α1-Antitrypsin Therapy

EC Lewis - Molecular medicine, 2012 - Springer
Abstract α 1-Antitrypsin (AAT) is a 52-kDa circulating serine protease inhibitor. Production of
AAT by the liver maintains 0.9-1.75 mg/mL circulating levels. During acute-phase responses …

Nanoparticles encapsulated with LL37 and serpin A1 promotes wound healing and synergistically enhances antibacterial activity

M Fumakia, EA Ho - Molecular pharmaceutics, 2016 - ACS Publications
Wound care is a serious healthcare concern, often complicated by prolonged inflammation
and bacterial infection, which contributes significantly to mortality and morbidity. Agents …

Immune-modulating effects of alpha-1 antitrypsin

MR Ehlers - Biological chemistry, 2014 - degruyter.com
Abstract Alpha-1 antitrypsin (AAT) is a circulating serine protease inhibitor (serpin) that
inhibits neutrophil elastase in the lung, and AAT deficiency is associated with early-onset …

Post-translational modifications of circulating alpha-1-antitrypsin protein

U Lechowicz, S Rudzinski, A Jezela-Stanek… - International Journal of …, 2020 - mdpi.com
Alpha-1-antitrypsin (AAT), an acute-phase protein encoded by the SERPINA1 gene, is a
member of the serine protease inhibitor (SERPIN) superfamily. Its primary function is to …

[PDF][PDF] Biomarcadores del estado inflamatorio: nexo de unión con la obesidad y complicaciones asociadas

M Zulet, B Puchau, C Navarro, A Marti… - Nutrición …, 2007 - SciELO Espana
El objetivo de este trabajo ha consistido en realizar una revisión de los biomarcadores que
actualmente se proponen como el nexo de unión entre la inflamación, la obesidad y …

Proteomic characterization of idiopathic pulmonary fibrosis patients: stable versus acute exacerbation

A Carleo, C Landi, A Prasse… - … Archives for Chest …, 2020 - monaldi-archives.org
Acute exacerbations (AEs) are among the main causes of death in idiopathic pulmonary
fibrosis (IPF) patients. In this study proteomic comparative analysis of bronchoalveolar …

Gingival crevicular fluid peptidome profiling in healthy and in periodontal diseases

M Preianò, R Savino, C Villella, C Pelaia… - International journal of …, 2020 - mdpi.com
Given its intrinsic nature, gingival crevicular fluid (GCF) is an attractive source for the
discovery of novel biomarkers of periodontal diseases. GCF contains antimicrobial peptides …

Alpha-1 antitrypsin in autoimmune diseases: Roles and therapeutic prospects

R Sun, Z Xu, C Zhu, T Chen, LE Muñoz, L Dai… - International …, 2022 - Elsevier
Abstract Alpha-1 antitrypsin (A1AT) is a protease inhibitor in the serum. Its primary function is
to inhibit the activity of a series of proteases, including proteinase 3, neutrophil elastase …

Cytoprotective role of alpha-1 antitrypsin in vascular endothelial cell under hypoxia/reoxygenation condition

Y Feng, L Hu, Q Xu, H Yuan, L Ba, Y He… - Journal of …, 2015 - journals.lww.com
Ischemia/reperfusion (IR) injury is a critical factor in the pathogenesis of tissue injury after
myocardial infarction, multiple organ failure, and other acute ischemic events. Previous …