Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …
computational predictions from primary structures, complements secondary and tertiary …
The PP1 binding code: a molecular‐lego strategy that governs specificity
E Heroes, B Lesage, J Görnemann… - The FEBS …, 2013 - Wiley Online Library
Ser/Thr protein phosphatase 1 (PP1) is a single‐domain hub protein with nearly 200
validated interactors in vertebrates. PP1‐interacting proteins (PIPs) are ubiquitously …
validated interactors in vertebrates. PP1‐interacting proteins (PIPs) are ubiquitously …
Exploring the binding diversity of intrinsically disordered proteins involved in one‐to‐many binding
Molecular recognition features (MoRFs) are intrinsically disordered protein regions that bind
to partners via disorder‐to‐order transitions. In one‐to‐many binding, a single MoRF binds …
to partners via disorder‐to‐order transitions. In one‐to‐many binding, a single MoRF binds …
Molecular recognition features (MoRFs) in three domains of life
Intrinsically disordered proteins and protein regions offer numerous advantages in the
context of protein–protein interactions when compared to the structured proteins and …
context of protein–protein interactions when compared to the structured proteins and …
Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes
Because of their pervasiveness in eukaryotic genomes and their unique properties,
understanding the role that ID (intrinsically disordered) regions in proteins play in the …
understanding the role that ID (intrinsically disordered) regions in proteins play in the …
DisoLipPred: accurate prediction of disordered lipid-binding residues in protein sequences with deep recurrent networks and transfer learning
Motivation Intrinsically disordered protein regions interact with proteins, nucleic acids and
lipids. Regions that bind lipids are implicated in a wide spectrum of cellular functions and …
lipids. Regions that bind lipids are implicated in a wide spectrum of cellular functions and …
Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response
MM Al Qaraghuli, K Kubiak-Ossowska, VA Ferro… - Scientific reports, 2020 - nature.com
Numerous monoclonal antibodies have been developed successfully for the treatment of
various diseases. Nevertheless, the development of biotherapeutic antibodies is complex …
various diseases. Nevertheless, the development of biotherapeutic antibodies is complex …
Extreme multifunctional proteins identified from a human protein interaction network
CE Chapple, B Robisson, L Spinelli, C Guien… - Nature …, 2015 - nature.com
Moonlighting proteins are a subclass of multifunctional proteins whose functions are
unrelated. Although they may play important roles in cells, there has been no large-scale …
unrelated. Although they may play important roles in cells, there has been no large-scale …
A systematic comparison of free and bound antibodies reveals binding-related conformational changes
To study structural changes that occur in Abs upon Ag binding, we systematically compared
free and bound structures of all 141 crystal structures of the 49 Abs that were solved in these …
free and bound structures of all 141 crystal structures of the 49 Abs that were solved in these …
[HTML][HTML] Computational prediction of MoRFs, short disorder-to-order transitioning protein binding regions
Molecular recognition features (MoRFs) are short protein-binding regions that undergo
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …