Mammals have potent innate immune systems that work together to fight against a variety of
distinct viruses. In addition to interferon (IFN) response, which has been intensively studied …

The foundation of all biological processes is the network of diverse and dynamic protein
interactions with other molecules in cells known as the interactome. Understanding the …

Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect>
95% of adults worldwide. Despite its central role in EBV persistence and oncogenesis, much …

Semliki Forest virus (SFV) is a neuropathogenic alphavirus which is of interest both as a
model neurotropic alphavirus and as an oncolytic virus with proven potency in preclinical …

Background RNA helicases are emerging as key factors regulating host-virus interactions.
The DEAD-box ATP-dependent RNA helicase DDX5, which plays an important role in many …

Kaposi's sarcoma-associated herpesvirus (KSHV) relies on many cellular proteins to
complete replication and generate new virions. Paraspeckle nuclear bodies consisting of …

Paraspeckles are non-membranous subnuclear bodies, formed through the interaction
between the architectural long non-coding RNA (lncRNA) nuclear paraspeckle assembly …

RNA-binding proteins (RBPs) provide a critical post-transcriptional regulatory layer in
determining RNA fate. Currently, UV crosslinking followed by oligo-dT pull-down is the …

The DEAD-box ATP-dependent RNA helicases DDX5 and DDX17 play an important role in
many aspects of cellular RNA biology, including metabolism, translation, splicing …

Mammalian species possess sophisticated innate immune mechanisms that collectively
combat a wide array of viral pathogens. Among these, the well-characterized interferon (IFN) …