The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Astrocytes‐derived extracellular vesicles (EVs) are key players in glia‐neuron
communication. However, whether EVs interact with neurons at preferential sites and how …

Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most
abundantly found in the outer membrane of neurons. Due to structural characteristics (a …

Prion, or PrPSc, is the pathological isoform of the cellular prion protein (PrPC) and it is the
etiological agent of transmissible spongiform encephalopathies (TSE) affecting humans and …

The prion protein (PrP) has been extensively studied because of its central role in a group of
neurodegenerative conditions collectively known as prion diseases. While a wealth of …

The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …

Corruption of cellular prion protein (PrPC) function (s) at the plasma membrane of neurons is
at the root of prion diseases, such as Creutzfeldt-Jakob disease and its variant in humans …

In the last decades, the role of the prion protein (PrP) in neurodegenerative diseases has
been intensively investigated, initially in prion diseases of humans (eg, Creutzfeldt-Jakob …

Cellular prion protein (PrP C) is a widely expressed glycosylphosphatidylinositol-anchored
membrane protein. Scrapie prion protein is a misfolded and aggregated form of PrP C …