Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …

Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-
induced hepatocarcinogenesis is a multistep process resulting from a combination of …

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials
through vacuole-mediated sequestration and subsequent delivery to lysosomes for …

In addition to causing cirrhosis and hepatocellular carcinoma, hepatitis C virus (HCV) is
thought to cause hypolipidemia, hepatic steatosis, insulin resistance, metabolic syndrome …

Hepatitis C Virus (HCV) induces intracellular events that trigger mitochondrial dysfunction
and promote host metabolic alterations. Here, we investigated selective autophagic …

Autophagy is a constitutive cellular process of degradation required to maintain homeostasis
and turn over spent organelles and aggregated proteins. For some viruses, the process can …

Lipid droplets (LD) have long been considered as mere fat drops; however, LD have lately
been revealed to be ubiquitous, dynamic and to be present in diverse organelles in which …

Hepatitis C virus (HCV) induces autophagosome formation in infected human hepatocytes.
We have previously reported that HCV exploits autophagic machinery in favor of virus …