Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer …
Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
Resveratrol nanoparticle attenuates metastasis and angiogenesis by deregulating inflammatory cytokines through inhibition of CAFs in oral cancer by CXCL-12/IL-6 …
Cancer-associated fibroblasts (CAFs) are one of the highly abundant components in the
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …
Roles of mitochondria in oral squamous cell carcinoma therapy: Friend or foe?
J Bai, L Wu, X Wang, Y Wang, Z Shang, E Jiang… - Cancers, 2022 - mdpi.com
Simple Summary Although many therapies have been applied in oral squamous cell
carcinoma, these therapies are still unsatisfactory. Recently, the mitochondrial role in oral …
carcinoma, these therapies are still unsatisfactory. Recently, the mitochondrial role in oral …
Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells
Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
Olaparib enhances the Resveratrol-mediated apoptosis in breast cancer cells by inhibiting the homologous recombination repair pathway
Although sensitization of BRCA-mutated, homologous recombination (HR)-deficient breast
cancer cells through PARP inhibitor is widely studied, not much is known about the …
cancer cells through PARP inhibitor is widely studied, not much is known about the …
Near-infrared enhances antiangiogenic potentiality of quinacrine-gold hybrid nanoparticles in breast cancer stem cells via deregulation of HSP-70/TGF-β
Aim: This study aimed to explore the antiangiogenic mechanism of quinacrine-gold hybrid
nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast …
nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast …
Talazoparib enhances the quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300
The presence of cancer stem cells (CSCs) in the tumor microenvironment (TME) is majorly
responsible for the development and recurrence of cancer. Earlier reports suggested that …
responsible for the development and recurrence of cancer. Earlier reports suggested that …
Combination of talazoparib and olaparib enhanced the curcumin-mediated apoptosis in oral cancer cells by PARP-1 trapping
Abstract Purpose Inhibition of Poly (ADP-ribose) Polymerases (PARP) results in the blocking
of DNA repair cascades that eventually leads to apoptosis and cancer cell death. PARP …
of DNA repair cascades that eventually leads to apoptosis and cancer cell death. PARP …
Combination of Resveratrol and PARP inhibitor Olaparib efficiently deregulates homologous recombination repair pathway in breast cancer cells through inhibition of …
Recently, we reported that a combination of a natural, bioactive compound Resveratrol
(RES) and a PARP inhibitor Olaparib (OLA) deregulated the homologous recombination …
(RES) and a PARP inhibitor Olaparib (OLA) deregulated the homologous recombination …
Nanotechnology at the crossroads of stem cell medicine
Nanotechnology is transforming stem cell medicine by enabling precise isolation, controlled
differentiation, and targeted therapies across various medical domains. This review …
differentiation, and targeted therapies across various medical domains. This review …