The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Abstract Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized
Ca2+-activated Cl-channel. Its gene has been mapped to an area on chromosome 11q13 …

Abstract Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major
complication of liver transplantation. Transmembrane member 16A (TMEM16A), a …

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts
gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion …

Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …

Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …

The calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated
OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

Identifying a universal biomarker for cancer treatment remains a major challenge in cancer
therapy. Extracellular exposure of phosphatidylserine (PS) is tightly regulated and is an “eat …