Spin hyperpolarization in modern magnetic resonance
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …
disciplines and in various practical applications, with medical magnetic resonance imaging …
In-cell NMR: Why and how?
FX Theillet, E Luchinat - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …
In Vivo Metabolic Imaging of [1‐13C]Pyruvate‐d3 Hyperpolarized By Reversible Exchange With Parahydrogen**
Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …
Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange
Despite great successes in oncology, patient outcomes are often still discouraging, and
hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of …
hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of …
Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]-Pyruvate
Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C] pyruvate in vivo
K MacCulloch, A Browning, DOG Bedoya… - Journal of magnetic …, 2023 - Elsevier
Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …
Order‐Unity 13C Nuclear Polarization of [1‐13C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement
Abstract Signal Amplification By Reversible Exchange in SHield Enabled Alignment Transfer
(SABRE‐SHEATH) is investigated to achieve rapid hyperpolarization of 13C1 spins of [1 …
(SABRE‐SHEATH) is investigated to achieve rapid hyperpolarization of 13C1 spins of [1 …
Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate
J Ettedgui, B Blackman, N Raju, SA Kotler… - Journal of the …, 2023 - ACS Publications
Hyperpolarized (HP) carbon-13 [13C] enables the specific investigation of dynamic
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
Yeast Solutions and Hyperpolarization Enable Real-Time Observation of Metabolized Substrates Even at Natural Abundance
Metabolic changes in an organism often occur much earlier than macroscopic
manifestations of disease, such as invasive tumors. Therefore, noninvasive tools to monitor …
manifestations of disease, such as invasive tumors. Therefore, noninvasive tools to monitor …
Rapid 13C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH
α-Ketoglutarate is a key biomolecule involved in a number of metabolic pathways─ most
notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with …
notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with …