Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

Bone metastases (BM) are a common complication of cancer, whose management often
requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with …

There are three distinct areas of cancer management that make bone health in cancer
patients of increasing clinical importance. First, bone metastases are common in many solid …

To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid
arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Metastatic bone disease (MBD) in advanced-stage cancer increases the risk of intractable
bone pain, pathological skeletal fracture, spinal-cord compression and decreased survival …

The rates of incident osteoporotic fractures seem to be stabilizing; however, fragility fractures
are still associated with considerable disability, costs and an increased risk of mortality …

Bone is in a constant state of remodeling, a process which was once attributed solely to
osteoblasts and osteoclasts. Decades of research has identified many other populations of …

Highlights•The most representative nanomaterials for bone drug delivery are summarized.•
Nanomaterials can target bone by oral, implant, injectable, and transdermal …