Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of
a family of translation repressor proteins, and a well-known substrate of mechanistic target of …

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

Disseminated disease is present in≈ 50% of colorectal cancer patients upon diagnosis,
being responsible for most of cancer deaths. Addition of biological drugs, as Bevacizumab …

The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a
phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative …

With the advances in high-throughput technologies, millions of somatic mutations have been
reported in the past decade. Identifying driver genes with oncogenic mutations from these …

Long noncoding RNAs (lncRNAs) contribute to many steps in carcinogenesis and often
serve as biomarkers or therapeutic targets for tumor diagnosis and therapy. Although the …

Background Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing
cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined …

CircRNAs (circular RNAs), recently identified as a critical regulator in tumorigenesis,
participate in CRC (colorectal cancer) growth. However, the role of hsa_circRNA_002144 in …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Liver metastasis is the most fatal event of colon cancer patients. Warburg effect has been
long challenged by the fact of upregulated oxidative phosphorylation (OXPHOS), while its …