Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

R Miao, C Jiang, WY Chang, H Zhang, J An, F Ho… - Immunity, 2023 - cell.com
Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

MP Murphy, H Bayir, V Belousov, CJ Chang… - Nature …, 2022 - nature.com
Multiple roles of reactive oxygen species (ROS) and their consequences for health and
disease are emerging throughout biological sciences. This development has led …

Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

A cytosolic surveillance mechanism activates the mitochondrial UPR

FXR Sutandy, I Gößner, G Tascher, C Münch - Nature, 2023 - nature.com
The mitochondrial unfolded protein response (UPRmt) is essential to safeguard
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …

Physiological signaling functions of reactive oxygen species in stem cells: from flies to man

SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Mitochondria: It is all about energy

A Casanova, A Wevers, S Navarro-Ledesma… - Frontiers in …, 2023 - frontiersin.org
Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

[HTML][HTML] Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) in plants–maintenance of structural individuality and functional blend

M Mandal, M Sarkar, A Khan, M Biswas, A Masi… - Advances in Redox …, 2022 - Elsevier
The free radicals along with several reactive oxygen species (ROS) and reactive nitrogen
species (RNS) are known to play a dual role in the biological living system which carries a …