▪ Abstract Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human
liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the …

Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …

Ethnicity is an important demographic variable contributing to interindividual variability in
drug metabolism and response. In this rapidly expanding research area many genetic …

Background: In a recent randomized intervention trial, the risk of prostate cancer for men
receiving a daily supplement of 200 µg selenium was one third of that for men receiving …

The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has
been reported to exhibit polymorphism among individual humans (Kleinbloesem, CH, van …

Cytochrome P450 phenotyping provides valuable information about real-time activity of
these important drug-metabolizing enzymes through the use of specific probe drugs. Despite …

Chemical carcinogens are usually chemically inert and require metabolic activation by
cellular enzymes to exert their detrimental effects. A particular compound can be activated …

Background: Pathways involved in androgen metabolism have been implicated in the
etiology of prostate cancer. The goal of this study was to evaluate the effect of CYP3A4, a …

The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes
containing CYP3A7 to metabolize midazolam were investigated using human hepatic …

The objective of this section is to evaluate the contributions of hepatic metabolism, intestinal
metabolism and intestinal p-glycoprotein to the pharmacokinetics of orally administered …