A novel approach to investigate the combinatorial effects of TLK1 (Tousled-Like Kinase1) inhibitors with Temozolomide for glioblastoma therapy

B Priya, D Chhabria, JM Dhongdi, S Kirubakaran - Bioorganic Chemistry, 2024 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive, incurable brain tumor with poor prognosis
and limited treatment options. Temozolomide (TMZ) is the standard chemotherapeutic …

In silico Design, Synthesis and Biological Evaluation of Novel Thieno[3,2‐d]pyrimidine Derivatives for Cancer Therapy – A Preliminary Study on the Inhibitory …

SN Sirakanyan, H Dilip, A Geronikaki… - Chemistry & …, 2024 - Wiley Online Library
Continuing our studies in the field of new heterocyclic compounds with biological interest,
herein we report the synthesis and anticancer activity of new N‐and S‐substituted …