Disease overview Chronic lymphocytic leukemia (CLL) is one of the most frequent types of
leukemia. It typically occurs in elderly patients and has a highly variable clinical course …

Abstract Disease Overview Chronic lymphocytic leukemia (CLL) is the commonest leukemia
in western countries. The disease typically occurs in elderly patients and has a highly …

Uniformly adopted response criteria are essential for assessment of therapies incorporating
conventional chemotherapy and chemoimmunotherapy regimens. Recently …

Thalidomide-like drugs such as lenalidomide are clinically important treatments for multiple
myeloma and show promise for other B cell malignancies. The biochemical mechanisms …

Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell
neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we …

In a phase 1 trial, idelalisib (GS-1101, CAL-101), a selective inhibitor of the lipid kinase
PI3Kδ, was evaluated in 54 patients with relapsed/refractory chronic lymphocytic leukemia …

Disease overview Chronic lymphocytic leukemia (CLL) is the commonest leukemia in
western countries. The disease typically occurs in elderly patients and has a highly variable …

Disease overview: Chronic lymphocytic leukemia (CLL) is the commonest leukemia in
western countries. The disease typically occurs in elderly patients and has a highly variable …

Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds
derived by modifying the chemical structure of thalidomide to improve its potency and …

Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined.
Here we demonstrate that impaired actin polymerization results in CD4+ and CD8+ T cells …