Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

Modern life poses many threats to good-quality sleep, challenging brain health across the
lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence …

Animal models of psychiatric disorders have been highly effective in advancing the field,
identifying circuits related to pathophysiology, and identifying novel therapeutic targets. In …

Currently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs)
and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to …

Marked dysregulation of the human prefrontal cortex (PFC) and anterior cingulate cortex
(ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of …

Background Childhood maltreatment can have detrimental consequences on individual well-
being and cognitive functioning. One type of childhood maltreatment that remains …

Prolonged daily intake of Western-type diet rich in saturated fats and sugars, and exposure
to early life stress have been independently linked to impaired neurodevelopment and …

Stress is a socio-environmental risk factor for the development of psychiatric disorders, with
the age of exposure potentially determining the outcome. Several brain regions mediate …

Background Stress has become a common public health concern, contributing to the rising
prevalence of psychiatric disorders. Understanding the impact of stress considering critical …

The nucleus reuniens of the thalamus (RE) is a pivotal area responsible for the connectivity
of the prefrontal-hippocampus pathway that regulates cognitive, executive, and fear learning …