Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells …

Gap junctions establish direct pathways for cells to transfer metabolic and electrical
messages. The local lipid environment is known to affect the structure, stability and …

Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Aims Connexin-based gap junctions are crucial for electrical communication in the heart;
they are each composed of two docked hemichannels (HCs), supplied as unpaired …

Abstract GJA8 encodes connexin 50 (Cx50), a transmembrane protein involved in the
formation of lens gap junctions. GJA8 mutations have been linked to early onset cataracts in …

Key points Gap junctions formed by different connexins are expressed throughout the body
and harbour unique channel properties that have not been fully defined mechanistically …

Connexins form large-pore channels that function either as dodecameric gap junctions or
hexameric hemichannels to allow the regulated movement of small molecules and ions …

In this review article, we summarize the current insight on the role of Connexin-and
Pannexin-based channels as modulators of sensory neurons. The somas of sensory …