Immunoproteasomes contain replacements for the three catalytic subunits of standard
proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that …

Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …

Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

The proteasome is a multi-catalytic protein complex whose primary function is the
degradation of abnormal or foreign proteins. Upon exposure of cells to interferons (IFNs), the …

The ubiquitin–proteasome system (UPS) is the main intracellular pathway for modulated
protein turnover, playing an important role in the maintenance of cellular homeostasis. It also …

Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper
folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …