The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …

In recent years small G proteins have become an intensively studied group of regulatory
GTP hydrolases involved in cell signaling. More than 100 small G proteins have been …

Clathrin-dependent endocytosis has long been presented as the only efficient mechanism
by which transmembrane receptors are internalized. We selectively blocked this process …

The proper function of Rho GTPases requires precise spatial and temporal regulation of
effector interactions. Integrin-mediated cell adhesion modulates the interaction of GTP-Rac …

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been reported to
reduce the risk of Alzheimer disease. We have shown previously that statins inhibit a β …

The development of broad-spectrum metallo-β-lactamase (MBL) inhibitors is challenging
due to structural diversity and differences in metal utilisation by these enzymes. Analysis of …

Resistance to β-lactam antibiotics mediated by metallo-β-lactamases is an increasingly
worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we …

Small GTPase Rac is a crucial regulator of actin cytoskeletal rearrangement, and it plays an
important role in cell spreading, migration, mitogenesis, phagocytosis, superoxide …

In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the
single most powerful form of spectroscopy in both chemistry and structural biology. The …

Many physiological and oncogenic activities of the'classical'Ras proteins (H-Ras, N-Ras and
K-Ras4A and-4B) require their correct localization to the plasma membrane. Nascent Ras …